TLDR - MCAS isn’t random. There are underlying causes (disruptions in the foundations) and these need to be addressed if you plan to reverse this condition.
Expanded
Your autonomic nervous system may mistakenly perceive harmless substances in your environment or diet as threats because your genes have expressed themselves differently. You weren't born with this sensitivity, so why did it occur? Changes in your environment, lifestyle, and mindset likely had the biggest impact on your gene expression, leading to this condition. As your gene expression changes, you become more sensitive to certain triggers, which now need to be reduced before healing can begin. The details below outline potential causes of this condition, but remember, everyone is unique. By following The Foundations, you can address these causes over time.
Environmental Factors
All of these trigger danger responses that need to be avoided as you heal.
Environmental Toxins
Mold Exposure: Chronic exposure to mold and mycotoxins.
Chemical Exposures: Pesticides, heavy metals, and other environmental pollutants.
Air Pollution: Particulate matter and other airborne contaminants.
Chronic Infections: Lyme disease, Epstein-Barr virus (EBV), and other viral, bacterial, or parasitic infections.
Candida Overgrowth: Fungal infections that can disrupt immune balance.
Temperature Extremes:
Exposure to extreme heat or cold.
Allergic Reactions:
Pollen, dust mites, pet dander, and other common allergens.
Consumption Factors
Overconsumption of processed and difficult to digest foods.
Over Use of Medications
NSAIDs: Nonsteroidal anti inflammatory drugs.
Opioids: Can trigger mast cell activation in some individuals.
Lifestyle Factors
Leaky Gut Syndrome: Increased intestinal permeability leading to systemic inflammation.
Dysbiosis: Imbalance in gut microbiota.
Hormonal Imbalances:
Thyroid Disorders: Hypothyroidism or hyperthyroidism.
Adrenal Dysfunction: Chronic adrenal stress and imbalance.
Vitamin and Mineral Deficiencies
Vitamin D Deficiency: Important for immune regulation.
Magnesium Deficiency: Affects numerous bodily functions.
Injuries or surgeries that can trigger mast cell activation.
Lifestyle Factors
Poor Diet: Nutrient poor and inflammatory diet.
Sedentary Lifestyle: Lack of physical activity.
Substance Abuse
Alcohol, recreational drugs, and smoking.
Mindset Factors
Chronic Stress and Emotional Trauma
Emotional Stress: Long term psychological stress and trauma.