VIP and Circadian Rhythm
TLDR - VIP plays a significant role in regulating circadian rhythms and is a important component in the treatment of CIRS. VIP is known to work by reversing gene expression, but the exact mechanisms is unknown. I believe that rebalancing circadian rhythms is a major factor in how VIP does this.
What is VIP?
VIP (Vasoactive Intestinal Peptide) is a neuropeptide that functions as a signaling molecule in various physiological processes. It is important in the suprachiasmatic nucleus (SCN), which is often referred to as the "master clock" of the body. The SCN is responsible for coordinating daily rhythms in behavior and physiology, synchronizing peripheral clocks in tissues throughout the body.
VIP and Circadian Rhythm
VIP is critical for maintaining a unified and coordinated circadian rhythm. It helps synchronize individual cellular clocks to the master clock, ensuring that physiological processes are properly timed. VIP generates daily rhythmic signals that are transmitted to other parts of the body, influencing sleep wake cycles, hormone release, metabolism, and other essential functions.
VIP Supplementation in CIRS Treatment
One of the final steps in CIRS treatment involves the use of VIP supplementation. It has multiple different functions with the biggest being the ability to reverse gene expression.
Reducing Inflammation: By modulating cytokine production, VIP helps reduce the persistent inflammation that is central to CIRS.
Normalizing Immune Function: VIP helps balance the immune response, preventing the overreaction to biotoxins that characterizes CIRS.
Improving Cognitive Function: Through its neuroprotective and neuromodulatory effects, VIP can help alleviate cognitive symptoms such as brain fog and memory issues.
Reversing Gene Expression Changes: VIP helps correct the gene expression abnormalities associated with chronic inflammation and immune dysfunction in CIRS.
Restoring Circadian Rhythms: Proper circadian function is essential for overall health. VIP helps synchronize the body’s internal clocks, which is often disrupted in CIRS patients.
The Link Between Circadian Dysregulation and CIRS
Circadian dysregulation is a significant issue in many CIRS patients. Disruptions in circadian rhythm can lead to many different health problems, including impaired immune response, increased inflammation, and altered gene expression. These disruptions may be a large contributor to the initial changes in gene expression seen in CIRS.
We see the various positive effects of VIP supplementation but do not fully understand its mechanisms. Could the core benefit be the correction of circadian rhythm? There are likely multiple contributing factors, but I believe this is a significant one.