TLDR - Binders are helpful when detoxing as they attach to toxins in the digestive tract.
How Binders Work
Binders work by adsorbing (binding to) toxins, heavy metals, and other harmful substances in the gastrointestinal tract. Once these toxins are bound to the binder, they can no longer be reabsorbed into the bloodstream and are excreted through your stool. This process helps reduce the overall toxic load in the body and supports the detoxification pathways of the liver, kidneys, and lymphatic system.
When to Take Binders
You will find slightly different recommendations for binders, but generally they should be taken on an empty stomach or at least 30 minutes to an hour before or after meals and other supplements. This timing helps ensure that the binder can efficiently adsorb toxins without interfering with the absorption of nutrients and medications. It's also important to drink plenty of water when taking binders to support the excretion process and prevent constipation.
Common Binders
Takesumi Supreme: Takesumi is a form of activated bamboo charcoal that has been traditionally used in Japanese medicine. It acts similarly to activated charcoal but may have additional benefits due to its unique composition. It is used for general detoxification, improving digestion, and supporting kidney function. This is my recommended binder for almost all situations.
Cholestyramine: A prescription medication that binds to bile acids in the intestines, preventing their reabsorption. This helps eliminate toxins that are excreted into the bile by the liver. If you go this route, you may need a compounded version, as the over the counter options often contain added sugars and other additives. This is the most common recommendation in CIRS treatment.
Welchol (Colesevelam): Similar to cholestyramine, Welchol binds to bile acids and aids in their excretion. It has a slightly different structure and can be more tolerable for some individuals. This is usually the second most recommended binder when treating CIRS.
Activated Charcoal: Activated charcoal has a porous structure that traps toxins and gases in the digestive system.
Bentonite Clay: Bentonite clay swells when it comes into contact with water, creating a sponge like structure that can bind to toxins and heavy metals.
Zeolite: Zeolites are microporous minerals that can trap heavy metals and toxins in their crystalline structure.
Psyllium Husk: Psyllium husk is a soluble fiber that can help bind toxins and support healthy bowel movements. It is also used for relieving constipation.
I don’t recommend spending money on testing for specific mycotoxins. If you already have, there are specific binder recommended for each mycotoxin.
Considerations
Start Low and Slow: Many binders can be harsh on the digestive system, especially when taken in large amounts or started abruptly. It's important to start with a low dose and gradually increase it as your body adjusts. This approach helps minimize potential side effects such as constipation, bloating, and discomfort.
Hydration: Always drink plenty of water when taking binders to prevent dehydration and support the elimination of toxins.
Timing: Take binders away from meals, medications, and supplements to avoid interference with absorption.
CIRS Specific Recommendations
Binders are very important to take if you have CIRS. If you’re working with a CIRS provider then they can prescribe you cholestyramine or Welchol. If you go the cholestyramine route, you may be very sensitive and will need to get it compounded. I would personally just stick to Takesumi Supreme and avoid the prescriptions.